May 19, 2021

PKD Education Series

Dr. York Pei, MD, FRCPC, FACP, FASN, Professor, Division of Nephrology, Department of Medicine at the University of Toronto, and Director at the Centre for Innovative Management of PKD, University Health Network, will be hosting three educational sessions on PKD over June 5, June 19 and July 10. Topics will include a clinical case discussion with PKD experts, managing the side-effects of vasopressin V2 receptor blockade in ADPKD, and healthy diet and intermittent fasting with ADPKD.

Clinical Case Discussion with PKD Experts - June 5, 2021 9:00 am - 10:30 am

This session (90 minutes) provided 4-6 challenging clinical case (selected in advance to be provided by Drs. Chapman, Pei, Torres and the audience) in management of patients with ADPKD. The case presentations covered management of (i) occult infection, (ii) difficult blood pressure control, (iii) liver toxicity on AVP V2R treatment, and (iv) intracranial aneurysm screening, and two additional cases provided by the audience. These case presentations were interactive, with audience polling quizzes at different stages of the presentation, followed by panel expert comments at the end.

Managing the side-effects of vasopressin V2 receptor blockade in ADPKD - June 19, 2021 9:00 am - 10:30 am EDT

This session consisted of two parts:

(1) Lecture (30 minutes and 10 minutes Q&A): Review renal physiology of water clearance and how reduced vasopressin (AVP) V2 receptor (V2R) signaling can lead to polyuria and altered renal hemodynamics. This session discussed how this knowledge can be applied for proper interpretation of kidney function changes and optimal management (i.e. polyuria and blood pressure control) of patients with pharmacologic AVP V2R blockage. Potential renal hemodynamic interaction of AVP V2R antagonist, ACEi/ARB, and SGLT2 inhibitor will also be reviewed.

(2) Interactive Case Presentation (45 minutes): Two to three cases (to be provided by Drs. Bichet and Pei) were presented with polling quizzes for the audience and comments by Drs. Bichet and Pei.

Healthy Diet, Intermittent Fasting and PKD - July 10, 2021 10:30 am - 12:00 pm EDT

This session consisted of two parts:

(1) Lecture (20 minutes and 10 minutes Q&A): Review: (i) recent preclinical studies of novel dietary intervention (e.g. caloric restriction, ketotic diet) in slowing experimental PKD progression; (ii) elements of a healthy diet; (iii) potential utility of intermittent fasting or time-restricted feeding for clinical treatment of ADPKD.

(2) Practical advice for a healthy diet by a registered RD and Open forum for Q&A (30 minutes).