In addition to kidney problems, other organs can be affected, including the liver, spleen, pancreas, vasculature, testes, seminal vesicles and intestines.

• A large percentage of people with ADPKD will develop liver cysts during their lifetime.
• Cardiovascular complications include high blood pressure, cerebral aneurysms and mitral valve prolapse (MVP), a condition where the valve separating the top and the bottom of the left side of the heart does not close properly. Sometimes this causes blood to leak back to the top part of the heart. This is called regurgitation and can be heard as a heart murmur.
• People with ADPKD have about a 5 to 10 percent risk of developing intracranial aneurysms and the percentage is higher if there is a family history of aneurysms.
• Gastrointestinal complications of ADPKD include diverticulosis caused by diverticula, out-pouchings of the large intestine (colon).