What’s the difference between PKD1 and PKD2 and how do I know which type I have?


The severity of the kidney disease caused by the ADPKD1 and ADPKD2 genes is slightly different. With the ADPKD1 gene, cyst development, the onset of high blood pressure and loss of kidney function appear earlier as compared to the ADPKD2 gene. A genetic test is the only way to tell which PKD gene an individual carries.